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Panorama DossierPrevalence of bovine tuberculosis in India

Dossier Posted on 2019-04-30 19:09:32

Prevalence of bovine tuberculosis in India

(Abstract from manuscript)

Authors

Sreenidhi Srinivasan(1,2), Laurel Easterling(1,2), Bipin Rimal(2), Xiaoyue Maggie Niu(3), Andrew J.K. Conlan(4), Patrick Dudas(2) & Vivek Kapur(1,2)*

(1) Department of Animal Science, The Pennsylvania State University, United States of America.
(2) The Huck Institutes of the Life Sciences, The Pennsylvania State University, United States of America.
(3) Department of Statistics, Eberly College of Science, The Pennsylvania State University, United States of America.
(4) Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, United Kingdom.

* Corresponding author: vkapur@psu.edu

The designations and denominations employed and the presentation of the material in this article do not imply the expression of any opinion whatsoever on the part of the OIE concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers and boundaries.
The views expressed in this article are solely the responsibility of the author(s). The mention of specific companies or products of manufacturers, whether or not these have been patented, does not imply that these have been endorsed or recommended by the OIE in preference to others of a similar nature that are not mentioned.

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Bovine tuberculosis (bTB) is a chronic disease of cattle that affects productivity and represents a major public health threat. Despite the considerable economic costs and zoonotic risk associated with the disease, accurate estimates of bTB prevalence are lacking in many countries, including India, where national control programmes are not yet implemented and the disease is considered endemic.

To address this critical knowledge gap, we performed a systematic review of the literature and a meta-analysis to estimate bTB prevalence in cattle in India, and provide a foundation for the formulation of rational disease control strategies and the accurate assessment of economic and health impact risks.

The literature search was performed in accordance with PRISMA guidelines and identified 285 cross-sectional studies on bTB in cattle in India across four electronic databases and handpicked publications. Of these, 44 articles were included, contributing a total of 82,419 cows and buffaloes across 18 states and one union territory.

Based on a random-effects (RE) meta-regression model, the analysis revealed a pooled prevalence estimate of 7.3% (95% confidence interval [CI]: 5.6 – 9.5) (see Fig. 4 and Table 7 in the original research article, entitled Prevalence of bovine tuberculosis in India: a systematic review and meta-analysis and published in Transboundary and Emerging Diseases [1]), indicating that there may be an estimated 21.8 million (95% CI: 16.6 – 28.4) infected cattle in India – a population greater than the total number of dairy cows in the United States of America. The analyses further suggest that production system, species, breed, study location, diagnostic technique, sample size and study period are likely moderators of bTB prevalence in India and need to be considered when developing future disease surveillance and control programmes.

Taken together with the projected increase in intensification of dairy production and the subsequent increase in the likelihood of zoonotic transmission, the results of our study suggest that attempts to eliminate tuberculosis from humans will require simultaneous consideration of bTB control in cattle populations in countries such as India.

DOI of the original research article published in Transboundary and Emerging Diseases: https://doi.org/10.1111/tbed.12915

References

  1. Srinivasan S., Easterling L., Rimal B., Niu X.M., Conlan A.J.K., Dudas P. & Kapur V. (2018). – Prevalence of bovine tuberculosis in India: a systematic review and meta-analysis. Transbound. Emerg. Dis., 2018, 1–14. https://doi.org/10.1111/tbed.12915.

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